منابع مشابه
PAMPs and DAMPs as triggers for DIC
BACKGROUND Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for treating ARDS patients, its effectiveness remains controversial. The aim of the current study was to investigate the effects of sivelestat in ARDS patients with evidence of incr...
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Aluminum salts have been widely used in vaccine formulations and, after their introduction more than 80 years ago, only few vaccine formulations using new adjuvants were developed in the last two decades. Recent advances in the understanding of how innate mechanisms influence the adaptive immunity opened up the possibility for the development of new adjuvants in a more rational design. The purp...
متن کاملPAMPs, MAMPs, DAMPs and others: an update on the diversity of plant immunity elicitors
Plants possess a broad array of defenses that could be actively expressed in response of pathogenic organisms or parasites but also following beneficial saprophytic microorganisms recognition. Specifically, there are compounds derived from these organisms and called elicitors that are perceived by the plant to induce a locally or systemically expressed resistance. The understanding of the physi...
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Multicellular animals detect pathogens via a set of receptors that recognize pathogen-associated molecular patterns (PAMPs). However, pathogens are not the only causative agents of tissue and cell damage: trauma is another one. Evidence is accumulating that trauma and its associated tissue damage are recognized at the cell level via receptor-mediated detection of intracellular proteins released...
متن کاملOptimizing cancer treatments to induce an acute immune response: radiation Abscopal effects, PAMPs, and DAMPs.
Clinical results indicate improved survival in poorly differentiated prostate cancer patients following a treatment schedule that maximizes hormone therapy prior to radiation. This may be because of a systemic immune response, called an abscopal effect. A literature review showed an association between acute infection and abscopal cancer remission. This led to the theory that, in the presence o...
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ژورنال
عنوان ژورنال: Journal of Intensive Care
سال: 2014
ISSN: 2052-0492
DOI: 10.1186/s40560-014-0065-0